| East Los Angeles Cobras | — | East Los Angeles | 1993 | — |
| Eau Claire Aris FC | National Premier Soccer League | — | 2009 | — |
| El Farolito Soccer Club | National Premier Soccer League | San Francisco | 1985 | Boxer Stadium |
| El Paso Coyotes | Major Arena Soccer League | — | 2016 | El Paso County Coliseum |
| El Paso Locomotive FC | USL Championship | El Paso | March 1, 2018 | New El Paso Ballpark |
| El Paso Patriots | A-League, USL League Two | El Paso | 1989 | Patriot Stadium |
| El Paso/Juarez Gamecocks | United Soccer League | — | 1984 | Estadio Olímpico Benito Juárez |
| Elizabeth S.C. | Cosmopolitan Soccer League | Union County | 1924 | — |
| Emigrantes das Ilhas | United States Adult Soccer Association | Brockton | 1987 | — |
| Erie Admirals S.C. | National Premier Soccer League | Erie | 2009 | — |
| Evansville Crush | Premier Arena Soccer League | — | 2010 | Metro Sports Center |
| Evergreen Diplomats | American Soccer League | — | 2014 | — |
| Evergreen FC | USL League Two | Leesburg | 2015 | — |
| Excelsior of Brooklyn | National Association of Base Ball Players | — | 1854 | — |