| Columbus Shooting Stars | USL League Two | — | — | Historic Crew Stadium |
| Columbus Xoggz | United Soccer League, A-League, USL Second Division | Columbus | 1993 | — |
| Connecticut Bicentennials | North American Soccer League | Hartford | 1975 | Yale Bowl, Trinity Health Stadium |
| Connecticut Wolves | A-League | — | 1993 | — |
| Connecticut Yankees | American Soccer League | Hartford | 1972 | Trinity Health Stadium |
| Criollos de Caguas FC | Liga Nacional de Fútbol de Puerto Rico | Caguas | 1981 | — |
| Croatian Eagles | United Premier Soccer League | — | 1922 | — |
| Crystal Palace Baltimore | USSF Division 2 Professional League | Baltimore | 2006 | — |
| CT United FC | MLS Next Pro | Bridgeport | January 9, 2024 | — |
| CT United FC | — | — | 2015 | Veterans Stadium |
| D.C. United | Major League Soccer | Washington, D.C. | 1994 | Audi Field |
| D.C. United Academy | U.S. Soccer Development Academy | — | 2005 | — |
| D.C. United U-23 | USL League Two | — | 2011 | Maryland SoccerPlex |
| Dakota Fusion FC | National Premier Soccer League | Fargo | — | — |
| Dallas Lightning | — | Dallas | 1993 | — |
| Dallas Roma F.C. | North Texas Premier Soccer Association | Dallas | 2000 | — |
| Dallas Sidekicks | Major Indoor Soccer League | — | 1984 | Reunion Arena |
| Dallas Sidekicks | Major Arena Soccer League | Allen | 2012 | Credit Union of Texas Event Center |
| Dallas Tornado | United Soccer Association | Dallas | 1967 | Cotton Bowl |
| Danbury United | — | Danbury | 2003 | — |
| Dayton Dutch Lions WFC | Women's Premier Soccer League | — | 2011 | Dayton Outpatient Center Stadium |
| Dayton Gemini | USL League Two | — | 2000 | Baujan Field |
| Delaware Dynasty | USL League Two | — | 2006 | — |
| Delaware Wizards | — | Wilmington | 1993 | — |
| Denver Avalanche | Major Indoor Soccer League | — | 1980 | McNichols Sports Arena |
| Denver Cougars | USL League Two | — | 1998 | — |
| Denver Dynamite | Premier Arena Soccer League | — | 2008 | — |
| Denver Dynamos | North American Soccer League | Denver | 1974 | Mile High Stadium |
| Denver Kickers | National Premier Soccer League | — | 1962 | — |
| Denver Summit FC | National Women's Soccer League | Centennial | January 30, 2025 | Centennial Stadium |
| Des Moines Menace | USL League Two | Des Moines | 1994 | Valley High School |
| Detroit Arsenal | National Premier Soccer League | Berkley | 1997 | — |
| Detroit City FC | USL Championship | Detroit | 2012 | Keyworth Stadium |
| Detroit Cougars | United Soccer Association | Detroit | 1967 | Tiger Stadium |
| Detroit Express | North American Soccer League | Detroit | 1978 | Pontiac Silverdome |
| Detroit Express | American Soccer League | — | 1981 | Pontiac Silverdome |
| Detroit Ignition | — | Plymouth | 2006 | USA Hockey Arena |
| Detroit Lightning | Major Indoor Soccer League | — | 1979 | — |
| Detroit Mustangs | — | Detroit | 1972 | — |
| Detroit United | United States Adult Soccer Association | — | 2002 | — |
| DFW Tornados | USL League Two | Bedford | 1986 | Toyota Stadium |
| Doxa Italia | United States Adult Soccer Association | — | 1997 | — |
| Duluth FC | National Premier Soccer League | Duluth | 2015 | Denfeld High School |
| DV8 Defenders | United States Adult Soccer Association | — | 1999 | — |
| East Los Angeles Cobras | — | East Los Angeles | 1993 | — |
| Eau Claire Aris FC | National Premier Soccer League | — | 2009 | — |
| El Farolito Soccer Club | National Premier Soccer League | San Francisco | 1985 | Boxer Stadium |
| El Paso Coyotes | Major Arena Soccer League | — | 2016 | El Paso County Coliseum |